PROTARGOL 2% solution

INSTRUCTIONS FOR MEDICAL ADMINISTRATION Protargol 2% solution Trade name: Protargol 2% solution International nonproprietary or generic name: Silver proteinate Dosage form: Solution for topical use. Compound: Composition per 100ml: Active ingredient: silver proteinate – 2g, Excipient: distilled water – up to 100ml. Description: Brown solution with a slightly bitter or slightly astringent taste, odorless. Protargol consists of proteins containing 7.8-8.3% silver ions. Pharmacotherapeutic group: Antiseptic. ATX code: R01AX10 Pharmacological properties: Pharmacodynamics. When ingested, silver proteinate dissociates to form silver ions, which have an astringent, antiseptic and anti-inflammatory effect. Silver ions actively suppress the reproduction of infectious agents by binding their DNA. The mechanism of action of silver proteinate is based on the fact that silver ions precipitate proteins on the damaged mucous membrane and form a protective film, which helps reduce the sensitivity of nerve endings and narrow blood vessels (this leads to a decrease in swelling), which in turn inhibits inflammatory reactions. Silver ions also inhibit the proliferation of various bacteria. Active against gram-positive and gram-negative bacteria: B. cereus, C. albicans, E. coli, P. aeruginosa, S. aureus, A. Niger, S. Аbony and others. Pharmacokinetics. When applied topically, it is practically not adsorbed. Indications for use. Symptomatic treatment of acute nasopharyngitis (runny nose), sinusitis. Contraindications. Hypersensitivity to the components of the drug, atrophic rhinitis, pregnancy and breastfeeding, children under 3 years of age. Method of administration and dose. Locally. Before using the drug, it is recommended to rinse and clean the nasal passages. Adults and children over 6 years old: 2-3 drops in each nasal passage 3 times a day. Children aged 3 to 6 years: 1-2 drops in each nasal passage 3 times a day. The course of treatment is 5-7 days. The effect of the drug appears 2-3 days after the first use. If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor. The drug should be used only according to the method of administration described above and, in the doses, specified in the instructions for use. If necessary, before using the drug, you should consult your doctor. Side effect. When using the drug, the following undesirable phenomena are possible: allergic reactions (skin itching, urticaria), irritation and numbness of the nasal mucosa, dryness of the oral mucosa, redness of the eyes, atopic dermatitis, Quincke's edema, anaphylactic shock. If you experience the side effects listed in the instructions, or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor. Overdose. Symptoms: with the recommended method of use, an overdose is unlikely. Possible increased side effects. If a large amount of the drug is accidentally swallowed, irritation of the gastrointestinal tract may occur. With prolonged uncontrolled use of the drug, it is theoretically possible that a very rare disease, argyrias, may develop (gray or bluish discoloration of the skin and mucous membranes). If the recommended dosage regimen is followed, the risk of developing argyrias is unlikely. Treatment: in case of severe irritation, burning, itching of the eyes, skin and mucous membranes, rinse with plenty of water for 15 minutes. Treatment is symptomatic. Interaction with other drugs Salts of zinc, copper, lead, silver, mercury, iron, aluminum form insoluble precipitates with a solution of silver proteinate; silver proteinate solution is inactivated by alkaloid salts and organic bases (epinephrine). If you are using the above or other medications (including over-the-counter medications), you should consult your doctor before using the drug. Special instructions. Before using the drug, carefully read these instructions for use. Save the instructions, you may need them again. If you have any questions, consult your doctor. The medicine you are using is intended for you personally and should not be given to others as it may cause harm to them even if they have the same symptoms as you. If any of the side effects indicated in the instructions worsen, treatment should be stopped. Nasal discharge may turn gray or blue. Do not exceed recommended doses, especially in children and the elderly. The drug should not come into contact with the eyes. Use during pregnancy and breastfeeding. The use of the drug during pregnancy and breastfeeding is contraindicated. The effect of the drug on the ability to drive vehicles and machinery. The drug does not affect the ability to drive vehicles or engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Release form. Solution for topical use 2%. 15 ml in plastic, light-proof dropper bottles or spray bottles. Vacation conditions. Available without a prescription. Best before date. 18 months. Do not use after the expiration date stated on the package. Storage conditions. Store in the original packaging at a temperature not exceeding +25C, protected from light, out of the reach of children. Manufacturer's name and address Esko-Pharm LLC Republic of Armenia, Yerevan 0079, st. Mikoyan 13 Tel.: (+37410) 673903 E-mail: farm-esco@mail.ru Owner of the Registration Certificate Esko-Pharm LLC Republic of Armenia, Yerevan 0079, st. Mikoyan 13 Tel.: (+37410) 673903 E-mail: farm-esco@mail.ru